I was having some problems with stuttering framerates at times after I installed the patch. A reinstall helped, but not as much as I was hoping.
I complete hard drive defrag really helped quite a bit. This is a huge install (11-12 gigs) and it needs to be sorted after you slap it on your hard drive.
That's pretty much true of any modern multi-gigabyte game. I need to remember to defrag my development machine at the office. It slows down over time, even though NTFS is supposed to be a lot more immune to fragmentation than FAT.
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Iliana: "You're a great friend but if we're ever chased by zombies I'm tripping you."
