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The secret is to get sentries, 1 dualie exo, and shotguns/nerve gas and see how long you can hold that room!
But according to violentsquirrel: "Sentries are for babies!"
Honestly, though, that would be epic except it falls off very quickly after the first wave, as the aliens are locked to spawning 3 at a time, or whatever the egg limit is.
After that, they stream in 1-2 at a time for a while until either
a) you expand and they have multiple valid targets (usually CC's) to attack simultaneously, or
b) they get stuck somewhere in the map geometry and the spawns pile up until the inevitable traffic jam frees itself and you get a giant wave hitting your base again.
The bots will also attack sentries. I was surprised when they took down field of sentries after field of sentries on their way to my base.